The comparison of paroxetine and gabapentin in the management of postmenopausal symptoms

Objective: To compare the clinical efficacy of gabapentin, an anticonvulsant agent, and paroxetine, a selective serotonin reuptake inhibitor in management post-menopausal symptoms. Methods: In this trial, two groups patients with menopause who had hot flashes were included. One group received gabapentin (600 mg daily, 23 cases) for 8 weeks. The other paroxetine (one capsule daily at morning or bedtime, MRS (Menopause Rating Scale) as well Beck’s Depression Inventory used to assess studied medications. Results: groups, flashes, sleep problems, muscle/joint pains, depression, irritability, anxiety, memory lack concentration severity significantly decreased after weeks treatment. Only urinary problems treatment did not show any significant difference. There was no difference dryness burning sensation before (P> 0.05). However, these changes (P <0.05). Conclusion: Both effective options decreasing menopausal symptoms namely heart discomfort, pains. addition, medications favorable results regarding psychological aspects menopause.